Nosocomial Mycobacterium bovis-bacille Calmette-Guérin infections due to contamination of chemotherapeutics: case finding and route of transmission.

نویسندگان

  • Margreet C Vos
  • Petra E W de Haas
  • Henri A Verbrugh
  • Nicole H M Renders
  • Nico G Hartwig
  • Peter de Man
  • Arend H J Kolk
  • Henk van Deutekom
  • J L Yntema
  • Arnold G Vulto
  • Marja Messemaker
  • Dick van Soolingen
چکیده

We studied nosocomial infections due to Mycobacterium bovis bacille Calmette-Guérin (BCG) Onco-TICE bacteria, transmitted by contamination of medication prepared in BCG Onco-TICE-contaminated hoods in the pharmacy, in 5 immunocompromised patients at 3 hospitals. The BCG strains cultured from the patients had the same DNA profile as the BCG Onco-TICE strain used for bladder instillation. To prevent these infections, a change from open to closed preparation was made; strictly separated preparation in time of BCG Onco-TICE instillation and chemotherapy was enforced, the biological safety cabinet was disinfected between preparations, and gloves were changed between preparations.

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عنوان ژورنال:
  • The Journal of infectious diseases

دوره 188 9  شماره 

صفحات  -

تاریخ انتشار 2003